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Additional info for IL2 type3 and IL10 Avia-B33 Wings and Wheels

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References . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1 Introduction A major goal of tissue engineering is to employ the principles of rational design to recreate appropriate signals to cells that promote biological processes leading to production of new tissues or repair of damaged ones. A key modulator of cell behavior is the ECM that provides individual cells with architectural cues of time and space, modulates bioavailability of soluble growth and differentiation factors, and organizes multicellular tissue development.

In general, cells attach to differentiate and carry out specialized cell functions such as secretion, absorption, or signal transmission. They detach in order to migrate and proliferate. Interestingly, many epithelia undergo a form of programmed cell death known as anoikis if forcibly detached from their substrata [18]. Elegant studies of migrating cells have shown simultaneous formation of focal adhesions with substrata on the leading edge of the cell, and dissolution of attachment sites on the trailing end [19].

This preparation contains tissue plasminogen activator as well as a number of growth factors including transforming growth factor β, epidermal growth factor, insulin-like growth factor 1, fibroblast growth factor 2, and platelet derived growth factor. Both these products form a gel at room temperature that will support growth and differentiation of cells grown on (or in) it as a two- or three-dimensional matrix. Serum also provides a variety of adhesion factors including fibronectin and vitronectin, along with a rich selection of soluble, circulating growth factors.

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IL2 type3 and IL10 Avia-B33 Wings and Wheels


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